Volatile Organic Compounds Determination from Intestinal Polyps and in Exhaled Breath by Gas Chromatography–Mass Spectrometry

In this paper, a new protocol is described, based on solid phase microextraction (SPME) coupled with gas chromatography–mass spectrometry (GC-MS), to monitor ex vivo changes in endogenous volatile organic compounds (VOCs) released by surgically resected colonic tissues (normal mucosa and adenomatous polyps) from seven patients undergoing operative colonoscopy identify their molecular pattern. The exhalated molecules these were sampled the ReCIVA® breath sampler, shortly before surgery, analyzed GC-MS. Comparing VOC patterns identified of same patients, possible correlation can be found between levels methylbenzene benzaldehyde exhaled presence polypoid lesions.